Trichloroethanol in Trichloroethylene Poisoning
نویسندگان
چکیده
منابع مشابه
Trichloroethanol in trichloroethylene poisoning.
Trichloroethylene and trichloroethanol were given intraperitoneally to guinea-pigs. Their effects were tested by measuring the threshold current intensity of electrical skin stimulation, the electrical excitability of the motor cerebral cortex, by recording and analysis of the electroencephalogram, and by electrocardiographic examination. The two compounds had similar effects on the nervous sys...
متن کامل[Trichloroethylene poisoning].
Trichloroethylene and trichloroethanol were given intraperitoneally to guinea-pigs. Their effects were tested by measuring the threshold current intensity of electrical skin stimulation, the electrical excitability of the motor cerebral cortex, by recording and analysis of the electroencephalogram, and by electrocardiographic examination. The two compounds had similar effects on the nervous sys...
متن کاملPolyneuritis cranialis associated with industrial trichloroethylene poisoning.
Trichloroethylene came into wide use as a solvent and degreasing agent during the First World War, and in 1915 the first cases of cranial nerve damage in workers exposed to this substance were reported. Further reports followed and it was suggested that the toxic agent was a contaminant (Defalque, 1961; Browning, 1965). Jackson (1934) published an account ofthe anaesthetic properties of trichlo...
متن کاملSex differences in metabolism of trichloroethylene and trichloroethanol in guinea pigs.
OBJECTIVES Trichloroethylene (TRI) has the potential to cause generalized dermatitis complicated with hepatitis. The guinea pig maximization test (GPMT) also suggests that both TRI and its metabolite trichloroethanol (TCE) exhibit immunogenicity and possible sex differences in guinea pigs. However, TRI and TCE metabolisms in guinea pigs have not been elucidated in detail. The first issue to cla...
متن کاملEnterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene.
Trichloroacetic acid (TCA) is a metabolite of trichloroethylene (TRI) thought to contribute to its hepatocarcinogenic effects in mice. Recent studies have shown that peak blood concentrations of TCA do not occur until approximately 12 hr after an oral dose of TRI; however, blood concentrations of TRI reach a maximum within 1 hr and is nondetectable after 2 hr. The objective of this study was to...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1966
ISSN: 1351-0711
DOI: 10.1136/oem.23.2.116